Key result
Single-particle cryoelectron microscopy has produced subnanometer (~10 Å) resolution structures of ryanodine receptors, revealing insights into their pore structure and gating mechanisms.
Population
Ryanodine-sensitive Ca2+ release channels (ryanodine receptors, RyRs), including RyR1, RyR2, and RyR3 isoforms
Design
Review
Authors
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Structural insights into ryanodine receptor gating offer no immediate clinical guidance; leaves open targeted drug development for arrhythmias.
Advances in cryo-electron microscopy have elucidated the three-dimensional structure and conformational states of ryanodine receptors, providing insights into their domain organization and gating mechanisms.
Hamilton et al. (2008) conducted a review in Ryanodine Receptor Structure. Single-particle cryoelectron microscopy has produced subnanometer (~10 Å) resolution structures of ryanodine receptors, revealing insights into their pore structure and gating mechanisms.
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