Key result
Diet-induced weight loss of greater than 5% over 24 weeks significantly reduced mean platelet volume in obese individuals compared to those who did not achieve significant weight loss (p < 0.01).
Why the study?
Does diet-induced weight loss reduce mean platelet volume and neutrophil lymphocyte ratio in people with obesity?
Cohort (n=186)
No
Does diet-induced weight loss reduce mean platelet volume and neutrophil lymphocyte ratio in people with obesity?
Diet-induced weight loss in individuals with obesity significantly reduces mean platelet volume, suggesting a potential decrease in platelet activation and cardiovascular risk.
May reduce platelet activation in obesity; hypothesis-generating for CV outcomes, requiring RCTs before practice change.
Objectives: To investigate is there a relationship between obesity parameters, mean platelet volume (MPV) and neutrophil lymphocyte ratio (NLR), and to examine is there a change in MPV and NLR level with weight loss. Material and Methods: The retrospective study consisted of two groups as the group losing weight after 24 weeks of diet (WLG) and the control group not losing weight (CG). Body mass index (BMI), MPV, NLR and lipid values of each group were recorded at the beginning and at the end of the study. Results: The study consisted of 186 individuals 94 of whom were in WLG and 92 were in CG. There was a statistically significant positive correlation between the initial value of MPV and BMI in WLG (p <0.05). There was a significant difference existed in the initial and final lipid parameters of WLG (p<0.0001). Changes in initial and final MPV values in WLG and CG were different from each other (p <0.01). The difference between the initial and final MPV values and BMI values in WLG was statistically significant (P <0.001). No significant correlation was found between obesity and weight loss with NLR. Conclusions: There was a statistically significant correlation between MPV and BMI. MPV levels decreased in obese individuals with weight loss. No correlation existed between BMI and NLR.
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Kurt et al. (2016) conducted a cohort in Obesity (n=186). Weight loss > 5% vs. Weight loss < 5% was evaluated on Change in mean platelet volume (MPV) (p=<0.01). Diet-induced weight loss of greater than 5% over 24 weeks significantly reduced mean platelet volume in obese individuals compared to those who did not achieve significant weight loss (p < 0.01).
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