Key result
Premature and sick infants requiring NICU admission had significantly higher levels of cord-blood hs-cTnI (p<0.01), with the 99th percentile for term infants established at 166.30 ng/L.
Why the study?
This study aimed to establish a reference interval for high-sensitivity cardiac troponin I in umbilical cord blood and evaluate its association with predetermined early neonatal outcomes.
Population
256 infants born between August 2015 and September 2015 at McMaster Children's Hospital
Comparison
Cord-blood hs-cTnI levels across clinical subgroups and outcomes
Design
Cohort study
Authors
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Provides cord-blood hs-cTnI reference intervals; associations with neonatal morbidity are hypothesis-generating and require prospective validation.
Observational (n=256)
No
Cord-blood hs-cTnI reference intervals were established for infants, demonstrating that premature and sick infants requiring NICU admission have significantly higher levels.
Ryan et al. (2021) conducted an observational in Neonatal outcomes (n=256). High-sensitivity cardiac troponin I (hs-cTnI) was evaluated on hs-cTnI reference interval and association with early neonatal outcomes. Premature and sick infants requiring NICU admission had significantly higher levels of cord-blood hs-cTnI (p<0.01), with the 99th percentile for term infants established at 166.30 ng/L.