Key result
Prophylactic intravenous ephedrine did not significantly decrease the incidence of maternal hypotension compared to normal saline (60% vs 72%; P > 0.05).
Why the study?
Does prophylactic intravenous ephedrine prevent maternal hypotension in primiparous parturients undergoing cesarean section under spinal anesthesia?
Population
50 primiparous parturients scheduled for cesarean section under spinal anesthesia
Comparison
1 ml of 5 mg bolus intravenous ephedrine… vs Equal volume of normal saline administered just…
Design
RCT, Randomly allocated into two groups
Authors
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Prophylactic ephedrine should not be used routinely for spinal hypotension in cesarean delivery; challenges prior assumptions of efficacy.
RCT (n=50)
randomly allocated
Does prophylactic intravenous ephedrine prevent maternal hypotension in primiparous parturients undergoing cesarean section under spinal anesthesia?
Absolute Event Rate: 60% vs 72%
p-value: p=> 0.05
A prophylactic 5 mg bolus of intravenous ephedrine does not significantly reduce the incidence of spinal-induced hypotension during cesarean section compared to normal saline.
Singh et al. (2016) conducted an RCT in cesarean section during spinal anesthesia (n=50). Intravenous ephedrine vs. Normal saline was evaluated on Incidence of hypotension (p=> 0.05). Prophylactic intravenous ephedrine did not significantly decrease the incidence of maternal hypotension compared to normal saline (60% vs 72%; P > 0.05).
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