Key result
Prophylactic intravenous ephedrine (0.5 mg/kg) significantly reduced the incidence of hypotension compared to saline (36.7% vs 80.0%, p<0.001) during spinal anesthesia for cesarean delivery.
Why the study?
Does prophylactic intravenous ephedrine reduce the incidence of hypotension in patients undergoing cesarean delivery under spinal anesthesia?
Population
60 patients undergoing cesarean delivery under spinal anesthesia
Comparison
Prophylactic bolus dose of 0.5 mg/kg intravenous… vs Intravenous saline given over 60 seconds shortly…
Design
RCT, randomly allocated, double-blinded
Authors
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Supports prophylactic ephedrine in cesarean spinal anesthesia; strengthens RCT evidence for obstetric vasopressor use.
RCT (n=60)
Double-blinded
Computer-generated code
No
Does prophylactic intravenous ephedrine reduce the incidence of hypotension in patients undergoing cesarean delivery under spinal anesthesia?
Absolute Event Rate: 36.7% vs 80%
p-value: p=<0.001
Prophylactic intravenous ephedrine (0.5 mg/kg) significantly reduces the incidence of hypotension and nausea/vomiting during spinal anesthesia for cesarean delivery.
Zahan et al. (2018) conducted an RCT in Hypotension during spinal anaesthesia for caesarean delivery (n=60). Ephedrine vs. Saline was evaluated on Incidence of hypotension (defined as 20% decrease in systolic arterial pressure from baseline) (p=<0.001). Prophylactic intravenous ephedrine (0.5 mg/kg) significantly reduced the incidence of hypotension compared to saline (36.7% vs 80.0%, p<0.001) during spinal anesthesia for cesarean delivery.
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