Key result
Prophylactic IV ephedrine infusion significantly reduced the incidence of spinal anesthesia-induced hypotension compared to fluid preload (24% vs 48%, p=0.03) during cesarean section.
Why the study?
Hypotension is a very common complication of spinal anesthesia during cesarean section that causes significant maternal and fetal morbidity and mortality.
Does IV ephedrine infusion prevent hypotension compared to volume preload in adult pregnant women undergoing spinal anesthesia for cesarean section?
Population
110 adult pregnant women who underwent caesarean delivery
Comparison
IV ephedrine vs volume preloading with 15 ml/kg Ringer lactate solution
Design
Prospective randomized comparative study
Authors
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Supports ephedrine infusion over fluid preload to prevent spinal hypotension in cesarean delivery; confirms superiority versus volume expansion in this RCT.
RCT (n=110)
Randomly allocated
No
Does IV ephedrine infusion prevent hypotension compared to volume preload in adult pregnant women undergoing spinal anesthesia for cesarean section?
Absolute Event Rate: 24% vs 48%
p-value: p=0.03
Prophylactic IV ephedrine infusion is more effective than fluid preload for preventing spinal anesthesia-induced hypotension during cesarean section.
Anam et al. (2019) conducted an RCT in Hypotension during spinal anesthesia for cesarean section (n=110). Prophylactic IV ephedrine vs. Volume preloading with 15 ml/kg Ringer lactate solution was evaluated on Incidence of hypotension (p=0.03). Prophylactic IV ephedrine infusion significantly reduced the incidence of spinal anesthesia-induced hypotension compared to fluid preload (24% vs 48%, p=0.03) during cesarean section.