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March 26, 2012Journal of Dairy ScienceOpen Access

Alterations of fatty acid β-oxidation capability in the liver of ketotic cows

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Key result

Ketotic cows exhibited altered liver fatty acid β-oxidation capability, with increased ACSL and decreased CPT I, CPT II, ACADL, HMGCS, and ACC expression compared to nonketotic cows.

Authors

PLPengcheng LiPLA Information Engineering UniversityXLXiaobing LiSouth China Agricultural UniversitySFShixin FuShenzhen University

Discussion

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Overview

Altered β-oxidation gene expression in ketotic cows is hypothesis-generating; leaves open mechanistic and therapeutic implications.

Study Design

Type

Case-Control (n=12)

PICO

P
Population
12 dairy cows (6 ketotic and 6 nonketotic) evaluated for liver fatty acid β-oxidation-related enzyme expression after parturition.
E
Exposure / Comparator
Ketosis vs Nonketotic cows
O
Primary Outcome
Expression of fatty acid β-oxidation-related enzymes in the liver

Cite This Study

Li et al. (2012) conducted a case-control in Ketosis (n=12). Ketosis vs. Nonketotic cows was evaluated on Expression of fatty acid β-oxidation-related enzymes in the liver. Ketotic cows exhibited altered liver fatty acid β-oxidation capability, with increased ACSL and decreased CPT I, CPT II, ACADL, HMGCS, and ACC expression compared to nonketotic cows.

synapsesocial.com/papers/6a9628ace011ca463da133aehttps://doi.org/10.3168/jds.2011-4580
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