Key result
HSV type 2 and VZV infections were associated with significantly higher CSF protein levels than enterovirus infection (medians 1205 and 974 vs 640 mg/L; P=0.001 and P=0.01, respectively).
Population
38 immunocompetent adults with PCR-positive viral meningitis (22 enterovirus, 8 HSV type 2, 8 VZV)
Design
Cohort
Authors
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Higher CSF protein in HSV-2/VZV meningitis may aid etiology differentiation; leaves open whether thresholds guide therapy without PCR.
Observational (n=38)
No
p-value: p=.001
In immunocompetent adults with viral meningitis, HSV-2 and VZV infections are associated with significantly higher CSF protein and white blood cell counts compared to enterovirus.
Ihekwaba et al. (2008) conducted an observational in Viral meningitis (n=38). Herpes simplex virus type 2 or Varicella zoster virus infection vs. Enterovirus infection was evaluated on Cerebrospinal fluid protein levels and white blood cell counts (p=.001). HSV type 2 and VZV infections were associated with significantly higher CSF protein levels than enterovirus infection (medians 1205 and 974 vs 640 mg/L; P=0.001 and P=0.01, respectively).