Key result
Regadenoson administration during myocardial perfusion imaging did not significantly prolong the QTc interval, though a positive stress ECG was statistically significant (p=0.0004).
Why the study?
The study was conducted to assess changes in QTc interval associated with Regadenoson administration during myocardial perfusion imaging.
Does Regadenoson administration cause QTc interval prolongation in patients undergoing pharmacological radionuclide MPI?
Observational (n=1,497)
Does Regadenoson administration cause QTc interval prolongation in patients undergoing pharmacological radionuclide MPI?
Regadenoson administration during myocardial perfusion imaging does not cause clinically significant QTc prolongation, supporting its safety profile.
Supports QTc safety of regadenoson in MPI; leaves open need for randomized confirmation.
The objective of our study is to assess change in QTc interval with Regadenoson administration during myocardial perfusion imaging (MPI). We conducted a retrospective, observational analysis of 1497 consecutive patients who underwent pharmacological radionuclide MPI. On multivariate logistic regression analyses, there was no statistical significance of QTc prolongation when adjusted for ischemia/fixed perfusion defect on MPI and QT prolonging medications being taken prior to stress testing. However, a positive stress ECG after Regadenoson injection had a statistical significance (p value 0.0004). Regadenoson is a safe drug for use in MPI with little, if any, side effects of major clinical significance.
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Rafiq et al. (2020) conducted an observational in Patients undergoing pharmacological radionuclide myocardial perfusion imaging (n=1,497). Regadenoson was evaluated on Change in QTc interval. Regadenoson administration during myocardial perfusion imaging did not significantly prolong the QTc interval, though a positive stress ECG was statistically significant (p=0.0004).
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