Key result
Regadenoson-induced ST elevation signals severe CAD despite reassuring SPECT perfusion imaging.
Why the study?
Transient ST-segment elevation ECG changes during regadenoson pharmacologic stress testing and their clinical significance were not well characterized.
Case Report (n=1)
May prompt consideration of angiography in select cases with regadenoson-induced ST changes; leaves open need for prospective validation before practice change.
Regadenoson is a pharmacologic stress agent that has been widely adopted as an alternative over other pharmacologic vasodilator agents due to its ease of use, patient tolerance, and safety profile. We report the case of dynamic ST-segment elevation electrocardiogram changes after regadenoson injection during an inpatient single-photon emission computed tomography myocardial perfusion stress test, with subsequent coronary angiography revealing the presence of hemodynamically significant coronary artery disease. Our findings confirm that transient regadenoson-induced ST-segment elevations are a marker for hemodynamically significant disease even in the setting of low-risk SPECT perfusion images.
No takes yet. Share an insight, caveat, or question.
Qamruddin et al. (2015) conducted a case report in Coronary artery disease (n=1). Regadenoson was evaluated on Hemodynamically significant coronary artery disease on coronary angiography. Transient regadenoson-induced ST-segment elevations indicated hemodynamically significant coronary artery disease despite low-risk SPECT perfusion images.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: