Key result
Recirculation during veno-venous ECMO increases with higher ECMO flow, decreases with higher cardiac output, and is substantially reduced by using a more peripheral drainage site.
Why the study?
How do ECMO flow, cardiac output, and cannulation sites affect recirculation in veno-venous ECMO?
How do ECMO flow, cardiac output, and cannulation sites affect recirculation in veno-venous ECMO?
Simulation models and clinical data suggest that recirculation in veno-venous ECMO is highly dependent on cannulation site and flow settings, which should be optimized using arterial oxygenation parameters.
No takes yet. Share an insight, caveat, or question.
May guide vv-ECMO cannulation choices; hypothesis-generating from animal data requiring clinical confirmation.
Broman et al. (2014) studied Reversible life-threatening respiratory failure requiring veno-venous ECMO (n=11). Veno-venous ECMO flow settings and cannulation sites was evaluated on Recirculation of oxygenated blood. Recirculation during veno-venous ECMO increases with higher ECMO flow, decreases with higher cardiac output, and is substantially reduced by using a more peripheral drainage site.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: