Key result
Simulations revealed that extracorporeal blood flow relative to cardiac output, SVC to IVC blood flow ratio, and cannula positioning had major influences (>20%) on recirculation fraction.
Why the study?
Recirculation in VV ECMO reduces gas transfer efficiency, but previous computational models were limited by fixed geometry.
A computational fluid dynamics model incorporating fluid-structure interaction identified cannula position, orientation, and flow ratios as major determinants of recirculation during VV ECMO.
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May refine VV ECMO recirculation modeling; leaves open effects on clinical practice.
Conrad et al. (2020) studied Venovenous extracorporeal membrane oxygenation (VV ECMO). Variation of operational parameters (extracorporeal flow, cannula position, flow ratio) vs. Baseline configuration was evaluated on Recirculation fraction. Simulations revealed that extracorporeal blood flow relative to cardiac output, SVC to IVC blood flow ratio, and cannula positioning had major influences (>20%) on recirculation fraction.
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