Key result
Off-pump CABG resulted in a higher rate of the 1-year composite outcome of death, nonfatal myocardial infarction, or repeat revascularization compared to on-pump CABG (9.9% vs 7.4%, P=0.04).
Why the study?
Does off-pump CABG improve short- and long-term composite outcomes compared to on-pump CABG in patients scheduled for urgent or elective CABG?
Population
2203 patients scheduled for urgent or elective CABG-only procedures at 18 Veterans Affairs medical centers.
Comparison
Off-pump coronary artery bypass grafting (CABG) vs On-pump coronary artery bypass grafting using…
Design
Review, randomized, single-blind
Follow-up
1 year
Authors
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Off-pump CABG may increase 1-year events versus on-pump; leaves open optimal technique in contemporary practice.
RCT (n=2,203)
Single-blind
Randomized
Yes
Does off-pump CABG improve short- and long-term composite outcomes compared to on-pump CABG in patients scheduled for urgent or elective CABG?
Absolute Event Rate: 9.9% vs 7.4%
p-value: p=0.04
In patients undergoing urgent or elective CABG, off-pump surgery was associated with worse 1-year composite outcomes and poorer graft patency compared to on-pump surgery.
Edwards et al. (2010) conducted an RCT in Coronary artery disease requiring CABG (n=2,203). Off-pump CABG vs. On-pump CABG was evaluated on 1-year composite of death from any cause, nonfatal myocardial infarction, or repeat revascularization (p=0.04). Off-pump CABG resulted in a higher rate of the 1-year composite outcome of death, nonfatal myocardial infarction, or repeat revascularization compared to on-pump CABG (9.9% vs 7.4%, P=0.04).
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