Key result
Severe fatty liver was confirmed only in 50- and 75-week-old PPARalpha (+/-):LDLR (+/-) mice, associated with enhanced expression of lipogenic enzymes and SREBP-1.
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No immediate clinical implications; extends mechanistic insights in mice but leaves translation to humans open.
Li et al. (2008) studied Hepatic lipid accumulation / fatty liver. Age (25, 50, 75, 100 weeks) was evaluated on Hepatic fat content, protein amounts, and mRNA levels of genes involved in hepatic lipid metabolism. Severe fatty liver was confirmed only in 50- and 75-week-old PPARalpha (+/-):LDLR (+/-) mice, associated with enhanced expression of lipogenic enzymes and SREBP-1.
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