Key result
A novel spectrofluorimetric method for midodrine determination showed a linear range of 0.1-2.0 μg/ml, with limits of detection and quantitation of 0.03 and 0.10 μg/ml, respectively.
A novel spectrofluorimetric method was developed and validated for the determination of midodrine in raw and tablet forms, suitable for content uniformity testing.
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May support midodrine content uniformity testing; leaves open routine adoption without further validation.
A novel, simple, sensitive method was developed for determining midodrine spectrofluorimetrically in both its raw pure form and its tablet form. This study is based on the native fluorescence of midodrine and discusses the optimum solvent used and the wavelength range. The presented method was then validated with respect to linearity, accuracy, precision, and limits of detection and quantitation. The constructed calibration curve showed a linear range of 0.1-2.0 μg/ml. The limit of detection and limit of quantitation values were 0.03 and 0.10 μg/ml respectively. Finally, content uniformity testing was applied according to the United States Pharmacopoeia by adapting the presented method.
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Omar et al. (2019) studied this question. Spectrofluorimetric method for midodrine determination was evaluated on Linear range, limit of detection, and limit of quantitation. A novel spectrofluorimetric method for midodrine determination showed a linear range of 0.1-2.0 μg/ml, with limits of detection and quantitation of 0.03 and 0.10 μg/ml, respectively.
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