Why the study?
Does acetylcholine, nitroglycerin, and dipyridamole affect coronary vasomotion in patients after cardiac transplantation?
Population
17 patients with angiographically normal coronary arteries 40 ± 51 months after cardiac transplantation.
Design
Cross-sectional
Authors
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Reveals conduit endothelial dysfunction with preserved smooth-muscle response post-transplant; leaves open role of vasomotor testing in surveillance.
Does acetylcholine, nitroglycerin, and dipyridamole affect coronary vasomotion in patients after cardiac transplantation?
Long-term after cardiac transplantation, patients exhibit endothelial dysfunction in conduit coronary arteries but preserved endothelium-independent vasodilation, along with reduced microcirculatory vasodilatory responses.
Hartmann et al. (1994) studied this question.
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