Key result
Bioactive nanogels endogenously generating nitric oxide prevented platelet activation and aggregation even in the presence of highly potent platelet activators like thrombin.
Why the study?
Because NO has a very short biological half-life in blood, endogenous generation of NO from blood-contacting materials is needed to prevent thrombus formation on artificial surfaces like extracorporeal membrane oxygenators.
Do NO-releasing nanogels prevent platelet activation and aggregation in blood plasma?
Do NO-releasing nanogels prevent platelet activation and aggregation in blood plasma?
Bioactive NO-releasing nanogels can prevent platelet activation and aggregation, offering a potential strategy to reduce thrombosis on artificial blood-contacting surfaces.
Nitric oxide (NO) plays a significant role in controlling the physiology and pathophysiology of the body, including the endothelial antiplatelet function and therefore, antithrombogenic property of the blood vessels. This property of NO can be exploited to prevent thrombus formation on artificial surfaces like extracorporeal membrane oxygenators, which when come into contact with blood lead to protein adsorption and thereby platelet activation causing thrombus formation. However, NO is extremely reactive and has a very short biological half-life in blood, so only endogenous generation of NO from the blood contacting material can result into a stable and kinetically controllable local delivery of NO. In this regards, highly hydrophilic bioactive nanogels are presented which can endogenously generate NO in blood plasma from endogenous NO-donors thereby maintaining a physiological NO flux. It is shown that NO releasing nanogels could initiate cGMP-dependent protein kinase signaling followed by phosphorylation of vasodilator-stimulated phosphoprotein in platelets. This prevents platelet activation and aggregation even in presence of highly potent platelet activators like thrombin, adenosine 5'-diphosphate, and U46619 (thromboxane A2 mimetic).
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Hosseinnejad et al. (2023) studied Thrombus formation. Bioactive nanogels generating nitric oxide was evaluated on Platelet activation and aggregation. Bioactive nanogels endogenously generating nitric oxide prevented platelet activation and aggregation even in the presence of highly potent platelet activators like thrombin.
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