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June 1, 1993Journal of Cellular Physiology

Mechanism of action of angiostatic steroids: Suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis

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Population

Cultured bovine aortic endothelial (BAE) cells

Comparison

Medroxyprogesterone acetate at 10 M, 10 M, 10 M… vs bFGF alone or control medium

Design

Preclinical

Authors

FBFrancine BleiNYU Langone HealthEWEL WilsonThe Honourable Society of Lincoln's InnPMPaolo MignattiYork St John University

Discussion

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Overview

Experimental data link MPA to PAI-1-mediated angiogenesis suppression; leaves open clinical translation in vascular disease.

Structured PICO

P
Population
Cultured bovine aortic endothelial (BAE) cells
I
Intervention
Medroxyprogesterone acetate (MPA) at 10(-6) M, 10(-7) M, 10(-8) M, and 10(-9) M, with or without basic fibroblast growth factor (bFGF) 3 ng/ml
C
Comparator
bFGF alone or control medium
O
Outcome
Plasminogen activator (PA) activity and plasminogen activator inhibitor type-1 (PAI-1) productionsurrogate

Angiostatic steroids such as medroxyprogesterone acetate inhibit angiogenesis by increasing PAI-1 synthesis, thereby suppressing plasminogen activator activity.

Cite This Study

Blei et al. (1993) studied this question.

synapsesocial.com/papers/6a962ee3169d13659822fa40https://doi.org/10.1002/jcp.1041550315
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ophthalmology: Principles and Concepts.1966 · 171 citations
  2. 2Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor.1991 · 178 citations
  3. 3Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.1990 · 458 citations