Population
Preclinical models including bovine genomic DNA, murine C2C12 myoblast cells, and fibroblast cell lines
Design
Preclinical
Authors
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MyoD-myostatin regulation may promote myoblast cell-cycle exit; extends molecular targets but leaves open any role in cardiac muscle remodeling.
The myostatin gene is a downstream target of MyoD, suggesting MyoD triggers myoblast withdrawal from the cell cycle by regulating myostatin expression.
Spiller et al. (2002) studied this question.
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