Key result
Serum levels of BLC, IL-12p40, MIG, and MIP-1delta were significantly increased in patients with calcific aortic valve disease compared to controls or those with coronary artery disease.
Why the study?
Calcific aortic valve disease involves inflammation as a key step, prompting investigation into serum inflammatory factor expression using antibody microarray techniques.
Are specific serum inflammatory cytokines elevated in patients with calcific aortic valve disease compared to controls or patients with coronary artery disease?
Observational (n=258)
No
Are specific serum inflammatory cytokines elevated in patients with calcific aortic valve disease compared to controls or patients with coronary artery disease?
BLC, IL-12p40, MIG, and MIP-1delta are significantly elevated in patients with calcific aortic valve disease and may serve as biomarkers for the condition.
Elevated cytokines may support CAVD biomarker research; cross-sectional data leave causal, prognostic, and therapeutic roles open.
BACKGROUND: Calcific aortic valve disease (CAVD) is a slowly progressive pathologic process associated with significant morbidity and mortality, CAVD is the most common valve heart disease in the elderly and a leading cause of aortic valve stenosis. Multiple steps characterize the process: inflammation, cell apoptosis, lipid deposition, renin-angiotensin system activation, extracellular matrix remodeling, and bone formation. This paper focuses on detecting and analyzing the expression of serum inflammatory factors in CAVD by antibody microarray techniques. METHODS: In this study, a total of 258 patients were included at Tianjin Chest Hospital between January 2017 and December 2018, subjects were divided into three groups: control, coronary artery disease (CAD), and CAVD. Blood samples were collected, and adipokine/cytokine/chemokine serum profiles were measured by antibody arrays. RESULTS: These data suggest that B-Lymphocyte Chemoattractant (BLC), Interleukin (IL)-12p40, monokine inducible by γ interferon (MIG), and Macrophage inflammatory protein (MIP)-1delta were significantly increased in CAVD compared to control or CAD. Furthermore, Real-time quantified PCR, Western blot assay, and Flow cytometer detection showed that these four cytokines/chemokines were from peripheral blood mononuclear cells. CONCLUSIONS: These findings suggest that BLC, IL-12p40, MIG, and MIP-1delta can be used as a marker to assess CAVD, which could have significant clinical implications.
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Fu et al. (2020) conducted an observational in Calcific aortic valve disease (n=258). Calcific aortic valve disease vs. Control or coronary artery disease was evaluated on Serum levels of B-Lymphocyte Chemoattractant, IL-12p40, MIG, and MIP-1delta. Serum levels of BLC, IL-12p40, MIG, and MIP-1delta were significantly increased in patients with calcific aortic valve disease compared to controls or those with coronary artery disease.
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