Key result
Higher blood pressure variability was significantly correlated with decreased renal function (creatinine r=0.306, P<0.01) and increased cardiac injury (r=0.083, P<0.01), but not vascular injury.
Why the study?
Although multiple measures of blood pressure variability have been proposed, whether they are better than mean blood pressure in predicting target organ injury remains unclear.
Does increased short-term blood pressure variability correlate with target organ damage in older patients with essential hypertension?
Observational (n=635)
Does increased short-term blood pressure variability correlate with target organ damage in older patients with essential hypertension?
Answers are grounded in this paper and cite their sources.
In older patients with essential hypertension, increased short-term blood pressure variability is associated with decreased renal function and increased left ventricular mass.
Background Although multiple measures of blood pressure variability (BPV) have been proposed, whether they are better than mean blood pressure in predicting target organs is unclear. We aimed to determine the relationship between short term BPV and target organ injury. Methods This study was a retrospective study, and 635 inpatients in the Department of Cardiology from 2015 to 2020 were selected. We divided participants into four groups on the basis of the quartiles of BPV. One‐way analysis of variance was used to compare the differences between the groups, and linear regression was used to analyze the relationship between BPV and target organ damage. Results The average age of 635 patients was 74.36 ± 6.50 years old. Among them, 354 of 627 patients had diminished renal function (56.5%), 221of 604 patients had associated left ventricular hypertrophy (36.6%), and 227 of 231 patients had carotid plaque formation (98.3%). The baseline data indicated significant differences in fasting glucose, total cholesterol, low‐density lipoprotein, creatinine, glomerular filtration rate, sex, calcium channel blocker use, and the rate of diminished renal function. Multiple linear regression analysis showed that BPV was negatively correlated with renal injury (creatinine: r = 0.306, p < 0.01; estimated glomerular filtration rate: r = 0.058, p < 0.01), and BPV is positively correlated with cardiac injury ( r = 0.083, p < 0.01). Elevated BPV was not found to be associated with vascular injury. Conclusion Renal function decreases with increasing BPV and left ventricular mass increases with increasing BPV.
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Jing et al. (2023) conducted an observational in essential hypertension (n=635). Blood pressure variability was evaluated on Target organ injury (renal, cardiac, and vascular) (r = 0.306 for creatinine; r = 0.083 for cardiac injury, p=<0.01). Higher blood pressure variability was significantly correlated with decreased renal function (creatinine r=0.306, P<0.01) and increased cardiac injury (r=0.083, P<0.01), but not vascular injury.
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