Key result
Beat-to-beat BP variability is linked to ~3 g/m2 higher LV mass index independent of BP level.
Why the study?
Is blood pressure variability associated with target organ damage independent of blood pressure level in untreated subjects?
Population
256 untreated Chinese subjects referred to a hypertension clinic
Design
Cross-sectional
Authors
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Beat-to-beat BP variability may identify higher target organ damage risk independent of mean BP; hypothesis-generating and should not yet change practice.
Observational (n=256)
Is blood pressure variability associated with target organ damage independent of blood pressure level in untreated subjects?
Short-term beat-to-beat blood pressure variability is more strongly associated with target organ damage than day-to-day home blood pressure variability, independent of absolute blood pressure levels.
Wei et al. (2014) conducted an observational in Hypertension (n=256). Blood pressure variability (beat-to-beat, 24-hour ambulatory, 7-day home) vs. Blood pressure level was evaluated on Target organ damage (left ventricular mass index, urinary albumin-to-creatinine ratio, pulse wave velocity). Blood pressure variability was associated with target organ damage independent of BP level in beat-to-beat recordings (e.g., LV mass index increased +2.97-3.53 g/m2; P<0.04), but less so in home recordings.
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