Key result
Synchronized diaphragmatic stimulation improved quality of life, NT-proBNP, cardiac function, and exercise tolerance over 12 months in a man with refractory NYHA Class III heart failure.
Why the study?
Does synchronized diaphragmatic stimulation improve symptoms and cardiac function in a patient with symptomatic HFrEF?
Case Report (n=1)
Does synchronized diaphragmatic stimulation improve symptoms and cardiac function in a patient with symptomatic HFrEF?
Synchronized diaphragmatic stimulation may be a feasible and beneficial novel extra-cardiac device therapy for symptomatic HFrEF, warranting further investigation in randomized trials.
Answers are grounded in this paper and cite their sources.
SDS may offer an extra-cardiac option in symptomatic HFrEF; single case leaves open need for randomized trials before any practice change.
Synchronized diaphragmatic stimulation (SDS) is a novel extra-cardiac device-based therapy for symptomatic heart failure with reduced ejection fraction. SDS provides imperceptible chronic stimulation of the diaphragm through a laparoscopically implanted system consisting of an implantable pulse generator and two sensing/stimulating leads affixed to the inferior surface of the diaphragm delivering imperceptible R-wave gaited pulses that alter intrathoracic pressure improving ventricular filling and cardiac output. We describe, in a man with a history of myocardial infarctions resulting in heart failure and persistent New York Heart Association Class III symptoms despite standard therapies, the successful implantation of SDS resulting in improved quality of life, N-terminal pro brain natriuretic peptide, cardiac function, and exercise tolerance through 12 months of follow-up. Randomized trials are now required to validate these findings.
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Goldberg et al. (2022) conducted a case report in Chronic Heart Failure (n=1). Synchronized diaphragmatic stimulation was evaluated on Quality of life, N-terminal pro brain natriuretic peptide, cardiac function, and exercise tolerance. Synchronized diaphragmatic stimulation improved quality of life, NT-proBNP, cardiac function, and exercise tolerance over 12 months in a man with refractory NYHA Class III heart failure.
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