Key result
Intraoperative 80% FiO2 did not significantly affect the incidence of postoperative delirium compared to 40% FiO2 in elderly patients undergoing laparoscopic surgery (18.35% vs 20.38%; P>0.05).
Why the study?
Postoperative delirium is common in elderly patients undergoing laparoscopic surgery for gastric and colorectal malignancies and may be affected by different fractions of inspired oxygen.
Does 40% FiO2 compared to 80% FiO2 reduce postoperative delirium in elderly patients undergoing laparoscopic surgery for gastric and colorectal malignancies?
RCT (n=662)
Double-blind
Random number table method
No
Does 40% FiO2 compared to 80% FiO2 reduce postoperative delirium in elderly patients undergoing laparoscopic surgery for gastric and colorectal malignancies?
Absolute Event Rate: 18.35% vs 20.38%
p-value: p=> 0.05
Different intraoperative oxygen concentrations (40% vs 80% FiO2) do not significantly affect the incidence of postoperative delirium in elderly patients undergoing laparoscopic gastrointestinal cancer surgery, though lower FiO2 may reduce postoperative atelectasis.
Authors
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40% FiO2 does not increase POD versus 80%; supports low-oxygen use to reduce atelectasis without raising delirium risk in elderly cancer surgery.
Lin et al. (2021) conducted an RCT in Gastric and colorectal malignancies (n=662). 80% fraction of inspired oxygen (FiO2) vs. 40% FiO2 was evaluated on Incidence of postoperative delirium (POD) (p=> 0.05). Intraoperative 80% FiO2 did not significantly affect the incidence of postoperative delirium compared to 40% FiO2 in elderly patients undergoing laparoscopic surgery (18.35% vs 20.38%; P>0.05).
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