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June 1, 1997Brain ResearchOpen Access

The role of nitric oxide in the pathophysiology of thromboembolic stroke in the rat

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Population

Male Wistar rats (n = 76) subjected to experimentally induced common carotid artery thrombosis (CCAT)

Comparison

Pharmacological manipulation of NO levels using… vs Vehicle

Design

Preclinical, randomly assigned

Follow-up

48 hours

Authors

NSNancy E. StaglianoUniversität TrierWDW. Dalton DietrichCURE International UKRPRenata Falchete do PradoDepartment of Aerospace Science and Technology

Discussion

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Implication

Hypothesis-generating for selective nNOS inhibition or NO donation in experimental stroke; prospective studies needed before clinical translation.

Structured PICO

P
Population
Male Wistar rats (n = 76) subjected to experimentally induced common carotid artery thrombosis (CCAT)
I
Intervention
Pharmacological manipulation of NO levels using L-NAME (non-specific eNOS/nNOS inhibitor), 7-NI (specific nNOS inhibitor), L-arginine (NO precursor), or SIN-1 (NO donor) administered immediately after CCAT
C
Comparator
Vehicle
O
Outcome
Behavioral outcomes (forelimb placing, water maze retention) and histopathology (neuronal injury)surrogate

In a rat model of thromboembolic stroke, specific nNOS inhibition or NO donation provides neuroprotection, whereas non-specific NOS inhibition worsens outcomes.

Cite This Study

Stagliano et al. (1997) studied this question.

synapsesocial.com/papers/6a96356f169d13659822fbbchttps://doi.org/10.1016/s0006-8993(97)00200-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase1994 · 1,578 citations
  2. 2Flow thresholds of functional and morphological damage of brain tissue.1983 · 206 citations
  3. 3Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage1995 · 366 citations
  4. 4An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.1990 · 1,211 citations
  5. 5Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.1986 · 2,724 citations