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June 1, 1992Neuroreport

Effect of NO synthase inhibition on NMDA- and ischaemia-induced hippocampal lesions

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Key result

L-NAME selectively decreased NMDA-induced CA1 lesions in rats but had no effect on AMPA toxicity or ischaemia-induced hippocampal damage.

Population

Rats subjected to hippocampal lesions induced by focal injection of NMDA or s-AMPA, or by 10 min of severe…

Design

Preclinical

Authors

CMClaudia MoncadaDLD. LekieffreDélégation Paris 5BAB. Mak ArvinQueens Hospital Center

Discussion

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Implication

NO synthase inhibition may selectively target NMDA toxicity in rats; leaves open translation to ischaemic neuroprotection.

Structured PICO

P
Population
Rats subjected to hippocampal lesions induced by focal injection of NMDA or s-AMPA, or by 10 min of severe forebrain ischaemia (4-vessel occlusion)
I
Intervention
NG-Nitro-L-arginine methylester (L-NAME) 20 or 40 mg kg-1
O
Outcome
Hippocampal CA1 lesions/damagesurrogate

Nitric oxide contributes to NMDA toxicity, but NO synthase inhibition does not protect against ischaemia-induced hippocampal lesions in this model.

Cite This Study

Moncada et al. (1992) studied Hippocampal lesions (NMDA-, AMPA-, or ischaemia-induced). NG-Nitro-L-arginine methylester (L-NAME) was evaluated on Hippocampal lesions. L-NAME selectively decreased NMDA-induced CA1 lesions in rats but had no effect on AMPA toxicity or ischaemia-induced hippocampal damage.

synapsesocial.com/papers/6ab76ff0f413105d45b99cfehttps://doi.org/10.1097/00001756-199206000-00020
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Also Consider

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