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May 1, 1997Clinical and Experimental Pharmacology and PhysiologyOpen Access

Non‐specific Inhibitors of Nitric Oxide Synthase Cause Myocardial Necrosis in the Rat

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Why the study?

Does acute nitric oxide inhibition by L-NAME cause myocardial necrosis in male Wistar rats?

Population

Male Wistar rats

Comparison

N omega-nitro-L-arginine methyl ester… vs Saline and D-NAME

Design

Preclinical

Follow-up

72 hours

Authors

HMHeitor MorenoGeneral / Preventive / LipidsLNLuciana Piovesan NathanUniversidade Estadual de Campinas (UNICAMP)KMKonradin MetzeUniversidade Estadual de Campinas (UNICAMP)

Discussion

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Implication

Suggests hemodynamic drivers of necrosis under acute NO inhibition in rats; hypothesis-generating and leaves open human relevance.

Structured PICO

Does acute nitric oxide inhibition by L-NAME cause myocardial necrosis in male Wistar rats?

P
Population
Male Wistar rats
I
Intervention
N omega-nitro-L-arginine methyl ester (L-NAME) administered as a single bolus injection (0.5, 1.5, 5.0, 15.0 and 45.0 mg/kg), in drinking water (20 mg/kg per day) for 72 h, or in vitro (45 micrograms/heart)
C
Comparator
Saline and D-NAME (45.0 mg/kg in vivo, 45 micrograms/heart in vitro)
O
Outcome
Myocardial necrosis evaluated under light microscopysurrogate

Acute inhibition of nitric oxide biosynthesis by L-NAME causes myocardial necrosis in rats, likely driven by increased blood pressure and reduced coronary flow.

Cite This Study

Moreno et al. (1997) studied this question.

synapsesocial.com/papers/6a90e2f268768914f682feeahttps://doi.org/10.1111/j.1440-1681.1997.tb01200.x
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.1992 · 794 citations
  2. 2Plasma Angiotensins in Anephric Humans1991 · 30 citations
  3. 3Signals for the Remodeling of the Cardiac Interstitium in Systemic Hypertension1991 · 21 citations