Answers are grounded in this paper and cite their sources.
α- and β-substituted N,N-diethylacrylamides undergo copper-mediated direct β-trifluoromethylation. The amide moiety acts as a directing group for the regio- and the stereo-controlled introduction of the trifluoromethyl group. The reaction is carried out under acidic conditions in the presence of Umemoto's reagent. This method does not require prefunctionalized substrates and delivers excellent stereoselectivity.
No takes yet. Share an insight, caveat, or question.
Besset et al. (2013) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: