The the role of eight weeks of combined high-intensity interval training in modulating intrahepatic FNDC5 protein and irisin levels in male rats with non-alcoholic steatohepatitis

MethodsThis research selected 40 male Sprague-Dawley rats (age: 8 weeks) with an average weight of 230 ± 20 grams.The rats were kept in the animal house of Shiraz University with an ambient temperature of 22-24°C, humidity of 45%, and a light-dark cycle of 12-12.The ethical principles of working with the animals in the study were considered per the Helsinki Declaration, and the code of ethics HighlightsWhat is current knowledge?Currently, the optimal exercise protocol to improve non-alcoholic steatohepatitis is still under discussion despite the proven benefits of exercise in treating fatty liver disease. What is new here?A new protocol of high-intensity intermittent exercise combining water and a treadmill has been presented.It has shown positive effects on the lipid metabolism mechanism in the liver of non-alcoholic steatohepatitis patients without caloric restriction.