Key result
Acetazolamide administration slowed VCO2 kinetics during exercise compared to control (MRT 75 vs 54 s), demonstrating impaired CO2 elimination in the nonsteady state.
Why the study?
Does acetazolamide alter CO2 output and ventilation kinetics during moderate- and heavy-intensity exercise in men?
Does acetazolamide alter CO2 output and ventilation kinetics during moderate- and heavy-intensity exercise in men?
Absolute Event Rate: 75% vs 54%
Carbonic anhydrase inhibition with acetazolamide slows VCO2 kinetics during exercise, demonstrating impaired CO2 elimination in the nonsteady state.
May warrant caution with acetazolamide during exercise; hypothesis-generating for ventilatory kinetics in clinical populations.
The effect of carbonic anhydrase inhibition with acetazolamide (Acz) on CO2 output (VCO2) and ventilation (VE) kinetics was examined during moderate- and heavy-intensity exercise. Seven men [24 +/- 1 (SE) yr] performed cycling exercise during control (Con) and Acz (10 mg/kg body wt iv) sessions. Each subject performed step transitions (6 min) in work rate from 0 to 100 W [below ventilatory threshold ( VET)]. VE and gas exchange were measured breath by breath. The time constant (tau) was determined for exercise VET by using a three-component model (fit from the start of exercise). VCO2 kinetics were slower in Acz ( VET, MRT = 75 +/- 10 s) than Con ( VET, MRT = 54 +/- 7 s). During VET kinetics were faster in Acz (MRT = 85 +/- 17 s) than Con (MRT = 106 +/- 16 s). Carbonic anhydrase inhibition slowed VCO2 kinetics during both moderate- and heavy-intensity exercise, demonstrating impaired CO2 elimination in the nonsteady state of exercise. The slowed VE kinetics in Acz during exercise
No takes yet. Share an insight, caveat, or question.
Scheuermann et al. (1999) studied this question. Acetazolamide vs. Control was evaluated on VCO2 kinetics (mean response time, MRT in seconds). Acetazolamide administration slowed VCO2 kinetics during exercise compared to control (MRT 75 vs 54 s), demonstrating impaired CO2 elimination in the nonsteady state.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: