Key result
Elevated troponins in non-cardiac conditions, such as pulmonary embolism and sepsis, correlate with prognosis, although the implications for clinical management remain unclear.
Elevated troponins in non-cardiac conditions carry prognostic value, though specific management strategies based on these elevations remain unclear.
Troponin elevations in non-cardiac illness inform prognosis but should not guide therapy; leaves open need for interventional studies.
Non-cardiac causes of elevated troponins are often overlooked, yet elevated troponins have been shown to closely correlate with the prognosis of these conditions. The clinical significance of elevated troponins in non-cardiac conditions are not completely known. Also, it is still unclear if these clinical conditions need to be managed differently when they lead to an increase in troponin levels. Some of the non-cardiac conditions in which elevated troponins are commonly found include: pulmonary embolism, end stage renal disease, Sepsis/ Systemic inflammatory response syndrome (SIRS) and critically ill patient, rhabdomyolysis, physical exercise, burns, drug toxicity and stroke. This article discusses the suggested etiology of elevated cardiac troponins in these conditions and the prognostic values they carry.
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A 2018 study conducted a review in Non-cardiac causes of elevated troponins. Elevated troponins in non-cardiac conditions was evaluated. Elevated troponins in non-cardiac conditions, such as pulmonary embolism and sepsis, correlate with prognosis, although the implications for clinical management remain unclear.
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