Key result
Heart rate recovery at one minute after the six-minute walk test was significantly attenuated in heart failure patients receiving beta-blockers (12 beats/min) compared to those not receiving beta-blockers (18 beats/min) and healthy controls (21 beats/min).
Why the study?
Does beta-blocker therapy affect heart rate recovery at one minute after a six-minute walk test in patients with stable systolic heart failure?
Cross-Sectional (n=161)
No
Does beta-blocker therapy affect heart rate recovery at one minute after a six-minute walk test in patients with stable systolic heart failure?
Absolute Event Rate: 12% vs 18%
p-value: p=0.0002
Heart rate recovery at one minute after a six-minute walk test is attenuated in heart failure patients on beta-blockers but correlates with exercise tolerance, offering an alternative to treadmill testing.
Attenuated post-6MWT HRR on beta-blockers warrants cautious interpretation in HF; leaves open its prognostic value versus treadmill testing.
BACKGROUND: Heart rate recovery at one minute of rest (HRR1) is a predictor of mortality in heart failure (HF), but its prognosis has not been assessed at six-minute walk test (6MWT) in these patients. OBJECTIVE: This study aimed to determine the HRR1 at 6MWT in patients with HF and its correlation with six-minute walk distance (6MWD). METHODS: Cross-sectional, controlled protocol with 161 individuals, 126 patients with stable systolic HF, allocated into 2 groups (G1 and G2) receiving or not β-blocker and 35 volunteers in control group (G3) had HRR1 recorded at the 6MWT. RESULTS: HRR1 and 6MWD were significantly different in the 3 groups. Mean values of HRR1 and 6MWD were: HRR1 = 12 ± 14 beat/min G1; 18 ± 16 beat/min G2 and 21 ± 13 beat/min G3; 6MWD = 423 ± 102 m G1; 396 ± 101 m G2 and 484 ± 96 m G3 (p < 0.05). Results showed a correlation between HRR1 and 6MWD in G1(r = 0.3; p = 0.04) and in G3(r = 0.4; p= 0.03), but not in G2 (r= 0.12; p= 0.48). CONCLUSION: HRR1 response was attenuated in patients using βB and showed correlation with 6MWD, reflecting better exercise tolerance. HRR1 after 6MWT seems to represent an alternative when treadmill tests could not be tolerated.
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Lindemberg et al. (2014) conducted a cross-sectional in Heart Failure (n=161). Beta-blocker therapy vs. Heart failure patients not receiving beta-blockers and healthy volunteers was evaluated on Heart rate recovery at one minute of rest (HRR1) after 6MWT (p=0.0002). Heart rate recovery at one minute after the six-minute walk test was significantly attenuated in heart failure patients receiving beta-blockers (12 beats/min) compared to those not receiving beta-blockers (18 beats/min) and healthy controls (21 beats/min).
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