Key result
Doxorubicin persisted in the heart, lungs, and spleen up to 10 days post-injection, with the DXR/DNA ratio being significantly higher in the heart and spleen compared to other organs in both rat strains.
Population
Two strains of rats
Design
Preclinical
Follow-up
up to 10 days
Authors
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May elucidate doxorubicin cardiotoxicity mechanisms in rats; leaves open translation to human dosing and monitoring.
Doxorubicin demonstrates prolonged retention and higher nuclear fixation in the heart and spleen of rats, which may provide mechanistic insight into its tissue-specific toxicities such as cardiotoxicity.
Chauffert et al. (1988) studied this question. Doxorubicin (DXR) was evaluated on DXR/DNA ratio (index of nuclear fixation). Doxorubicin persisted in the heart, lungs, and spleen up to 10 days post-injection, with the DXR/DNA ratio being significantly higher in the heart and spleen compared to other organs in both rat strains.
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