Key result
Obstructive sleep apnoea independently increased the risk for incident coronary heart disease (HR 1.36; 95% CI 1.12 to 1.64; p=0.0014), with a more pronounced effect in women.
Why the study?
Does obstructive sleep apnoea increase the risk of coronary heart disease, type 2 diabetes, and diabetic complications in the general population?
Cohort (n=36,963)
Yes
Does obstructive sleep apnoea increase the risk of coronary heart disease, type 2 diabetes, and diabetic complications in the general population?
Hazard Ratio: 1.36 (95% CI 1.12–1.64)
p-value: p=0.0014
Obstructive sleep apnoea is an independent risk factor for coronary heart disease, type 2 diabetes, and diabetic kidney disease, with a particularly pronounced risk for coronary heart disease in women.
OSA may heighten CHD risk more in women; extends prior data but leaves open causal confirmation and screening impact.
OBJECTIVE: To evaluate if obstructive sleep apnoea (OSA) modifies the risk of coronary heart disease, type 2 diabetes (T2D) and diabetic complications in a gender-specific fashion. DESIGN AND SETTING: A longitudinal population-based study with up to 25-year follow-up data on 36 963 individuals (>500 000 person years) from three population-based cohorts: the FINRISK study, the Health 2000 Cohort Study and the Botnia Study. MAIN OUTCOME MEASURES: Incident coronary heart disease, diabetic kidney disease, T2D and all-cause mortality from the Finnish National Hospital Discharge Register and the Finnish National Causes-of-Death Register. RESULTS: After adjustments for age, sex, region, high-density lipoprotein (HDL) and total cholesterol, current cigarette smoking, body mass index, hypertension, T2D baseline and family history of stroke or myocardial infarction, OSA increased the risk for coronary heart disease (HR=1.36, p=0.0014, 95% CI 1.12 to 1.64), particularly in women (HR=2.01, 95% CI 1.31 to 3.07, p=0.0012). T2D clustered with OSA independently of obesity (HR=1.48, 95% CI 1.26 to 1.73, p=9.11×[Formula: see text]). The risk of diabetic kidney disease increased 1.75-fold in patients with OSA (95% CI 1.13 to 2.71, p=0.013). OSA increased the risk for coronary heart disease similarly among patients with T2D and in general population (HR=1.36). All-cause mortality was increased by OSA in diabetic individuals (HR=1.35, 95% CI 1.06 to 1.71, p=0.016). CONCLUSION: OSA is an independent risk factor for coronary heart disease, T2D and diabetic kidney disease. This effect is more pronounced even in women, who until now have received less attention in diagnosis and treatment of OSA than men.
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Strausz et al. (2018) conducted a cohort in Obstructive sleep apnoea (n=36,963). Obstructive sleep apnoea vs. Individuals without obstructive sleep apnoea was evaluated on Incident coronary heart disease (HR 1.36, 95% CI 1.12 to 1.64, p=0.0014). Obstructive sleep apnoea independently increased the risk for incident coronary heart disease (HR 1.36; 95% CI 1.12 to 1.64; p=0.0014), with a more pronounced effect in women.
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