Key result
Individuals with at least one APOE2 allele had a significantly higher risk of obstructive sleep apnea syndrome compared to those with no APOE2 alleles (OR 9.37; 95% CI 1.13-77.7; p=0.019).
Why the study?
Are specific APOE genetic variants associated with an increased risk of obstructive sleep apnea syndrome?
Observational (n=73)
Are specific APOE genetic variants associated with an increased risk of obstructive sleep apnea syndrome?
Odds Ratio: 9.37 (95% CI 1.13–77.7)
p-value: p=0.019
The presence of the APOE2 allele is associated with a significantly increased risk of obstructive sleep apnea syndrome.
APOE2-OSA association should not change practice; hypothesis-generating for genetic risk studies in larger cohorts.
BACKGROUND: Clinical and epidemiological studies indicate that obstructive sleep apnea syndrome (OSAS) has a strong genetic basis. OBJECTIVES: To investigate the apolipoprotein E (APOE) alleles as a genetic risk factor in OSAS. METHODS: A total of 73 patients (37 male) were included. All underwent full-night polysomnography and were evaluated for APOE alleles. RESULTS: The mean age was 51 ± 12 years. Forty-two of the patients had OSAS. The APOE3 allele was found in 97.3% (71/73) of the study population. The most common APOE genotype was E3/E3 (55/73, 75.3%). Compared to the individuals with no APOE2 alleles (E3/E3, E3/E4), the individuals with at least one APOE2 allele (E2/E3, E2/E4) had a 9.37-fold greater OSAS risk (OR = 9.37, 95% CI 1.13-77.7, p = 0.019). The individuals with APOE2 alleles (E2/E3, E2/E4) compared to the individuals with only an E3/E3 allele genotype had a 10-fold greater OSAS risk (OR = 10.3, 95% CI 1.24-86.61, p = 0.0308). Compared to the individuals with no APOE4 alleles (E2/E3, E3/E3), the individuals with APOE4 alleles (E2/E4, E3/E4) had a high but insignificant risk for OSAS (OR = 2.9, 95% CI 0.55-15.05, p = 0.286). The individuals with APOE4 alleles (E2/E4, E3/E4) compared to APOE3 alleles (E3/E3) had an increased but insignificant risk for OSAS (OR = 3.62, 95% CI 0.96-19.05, p = 0.127). CONCLUSION: Specific APOE genotypes are associated with OSAS in a high-risk population.
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Uyrum et al. (2015) conducted an observational in Obstructive Sleep Apnea Syndrome (OSAS) (n=73). Presence of at least one APOE2 allele vs. Individuals with no APOE2 alleles (E3/E3, E3/E4) was evaluated on OSAS risk (OR 9.37, 95% CI 1.13-77.7, p=0.019). Individuals with at least one APOE2 allele had a significantly higher risk of obstructive sleep apnea syndrome compared to those with no APOE2 alleles (OR 9.37; 95% CI 1.13-77.7; p=0.019).
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