Key result
Higher baseline serum calcium linked to ~149% greater 6-month readmission risk in heart failure.
Why the study?
The relationship between serum calcium and readmission within 6 months in patients with heart failure was unknown.
Do higher serum calcium levels increase the risk of readmission within 6 months in patients with heart failure?
Cohort (n=1,899)
No
Do higher serum calcium levels increase the risk of readmission within 6 months in patients with heart failure?
Odds Ratio: 2.49 (95% CI 1.27–4.87)
p-value: p=0.008
Higher baseline serum calcium levels are linearly and independently associated with an increased risk of 6-month readmission in patients with heart failure.
Serum calcium may associate with 6-month HF readmission; hypothesis-generating and requires prospective validation before any clinical use.
The relationship between serum calcium and readmission within 6 months in patients with heart failure (HF) is currently unknown. Therefore, we aimed to investigate whether serum calcium was independently related to readmission within 6 months in patients with HF after adjusting for other covariates. A total of 2008 patients who underwent HF were enrolled to determine the relationship between serum calcium levels and readmission within 6 months. Participants were divided into 2 categories based on serum calcium quartiles. The relationships between serum calcium and readmission within 6 months were analyzed via multivariable logistic regression models. The results of the multivariable logistic regression analysis showed that serum calcium at baseline increased the risk of readmission within 6 months after confounders were adjusted (odds ratio = 2.49, 95% confidence interval: 1.27-4.87). Moreover, when serum calcium was transformed into a categorical variable and the first quartile was used as a reference, the odds ratios and 95% confidence intervals of the second to fourth quartiles were 1.26 (0.93-1.7), 1.38 (1.0-1.9), and 1.55 (1.11-2.17), respectively, with a P-value for trend of .012. Furthermore, curve fitting revealed that serum calcium and readmission within 6 months were linearly related. Serum calcium is positively associated with readmission within 6 months in patients with HF, and the relationship between these factors is linear.
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Wei et al. (2025) conducted a cohort in Heart failure (n=1,899). Serum calcium levels vs. Lower serum calcium levels (first quartile) was evaluated on Readmission within 6 months (OR 2.49, 95% CI 1.27-4.87, p=0.008). Higher baseline serum calcium levels were independently associated with an increased risk of readmission within 6 months in patients with heart failure (OR 2.49).
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