Key result
Phenoxybenzamine is an alpha-adrenergic antagonist with diverse perioperative applications, though its regular use is limited by prolonged hypotensive effects.
Why the study?
What are the mechanisms of action, perioperative uses, and controversies surrounding the use of phenoxybenzamine?
What are the mechanisms of action, perioperative uses, and controversies surrounding the use of phenoxybenzamine?
Phenoxybenzamine has diverse perioperative and cardiovascular applications, though its prolonged hypotensive effect limits its regular clinical use.
Prolonged hypotension limits routine phenoxybenzamine use; leaves open need for comparative trials on alternatives in perioperative settings.
Phenoxybenzamine (PBZ) is an alpha adrenergic antagonist, used for the management of hypertension. PBZ acts by blocking alpha-adrenergic receptors, leading to vasodilatation and low systemic vascular resistance. This helps in control of blood pressure in pheochromocytoma, improvement of systemic oxygen delivery, and optimization of the Qp/Qs in pediatric cardiac surgery such as hypoplastic left heart syndrome and improving perfusion parameters during open heart surgery. The uses have further extended to causalgia, Raynaud's phenomenon, autonomic hyperreflexia, and even for patency of radial artery conduit in coronary artery bypass grafting surgery. However, its prolonged hypotensive effect limits the regular use. In this review, we discussed the mechanism of action, pharmaco-physiology of PBZ, perioperative uses in different clinical setting and controversies for its uses; publications in different scientific journals from the previous years.
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Das et al. (2017) conducted a review in Hypertension and perioperative settings. Phenoxybenzamine was evaluated. Phenoxybenzamine is an alpha-adrenergic antagonist with diverse perioperative applications, though its regular use is limited by prolonged hypotensive effects.
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