The increase in heart rate and cardiac output produced by intravenous phenoxybenzamine in dogs is primarily mediated by baroreceptor reflexes acting through sympathetic cardiac nerves or circulating catecholamines, rather than a direct cardiac action.
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Indicates baroreflex mediation of phenoxybenzamine effects in dogs; challenges direct-action assumptions and leaves human relevance open.
Fowler et al. (1970) studied this question.
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