Why the study?
Does intracoronary propranolol or phenoxybenzamine cause coronary vasodilation independent of adrenergic blockade in closed-chest dogs?
Population
Closed-chest dogs, including reserpinized dogs with coronary perfusion with red-cell Tyrode solution
Comparison
Intracoronary injection of propranolol or… vs Non-treated dogs (for the reserpinized comparison)
Design
Preclinical
Authors
Loading...
Animal data suggest non-adrenergic coronary effects of these agents; hypothesis-generating and should not change practice.
Does intracoronary propranolol or phenoxybenzamine cause coronary vasodilation independent of adrenergic blockade in closed-chest dogs?
Propranolol and phenoxybenzamine induce coronary vasodilation through non-adrenergic mechanisms, likely related to other pharmacological properties such as local anesthetic effects.
Hiroyasu Ito (1969) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: