Key result
Non-ST elevated myocardial infarction (NSTEMI) was associated with significantly higher levels of malondialdehyde (3.14 vs 1.49 µmol/L) and ischemia modified albumin, and lower levels of superoxide dismutase and catalase compared to healthy controls.
Why the study?
Diagnosis of NSTEMI is challenging when electrocardiography is normal and troponin parameters are only slightly higher than normal.
Are levels of oxidative stress biomarkers (IMA, MDA, SOD, and catalase) altered in patients with NSTEMI compared to healthy subjects?
Cross-Sectional (n=110)
No
Are levels of oxidative stress biomarkers (IMA, MDA, SOD, and catalase) altered in patients with NSTEMI compared to healthy subjects?
Absolute Event Rate: 3.14% vs 1.49%
p-value: p=<0.001
Blood concentrations of oxidant and antioxidant parameters (IMA, MDA, SOD, catalase) are significantly altered in NSTEMI patients and could help assess their oxidative state.
Altered IMA, MDA, SOD, and catalase levels suggest oxidative imbalance in NSTEMI; leaves open diagnostic utility pending validation studies.
Non-ST elevated myocardial infarction (NSTEMI) diagnosis is difficult when the electrocardiography (ECG) normal and troponin parameters are slightly higher than the normal reference range. This study aimed to assess the IMA (ischemia modified albumin), MDA (malondialdehyde), SOD (superoxide dismutase), and catalase in patients with NSTEMI. The present study included 55 patients with NSTEMI and 55 healthy subjects prospectively. IMA, MDA, SOD, and catalase levels were measured from venous blood obtained from each patient within twelve hours after the onset of symptoms. Differences between the two groups were evaluated with Student's unpaired t -test for parameters with a normal distribution. IMA (3.14 0.06 vs. 1.49 0.03) and MDA (3.14 0.06 vs. 1.49 0.03) were higher, and SOD (1.10 0.03 vs. 2.31 0.02) and catalase (0.54 0.02) vs. 0.22 0.02) were lower in NSTEMI patients than control subjects. There was a significant correlation among IMA, MDA, SOD and catalase. Our data reveal that levels of MDA and IMA were increased, and SOD and catalase levels were decreased significantly in patients with NSTEMI. Blood concentrations of oxidant and antioxidant parameters could assess the oxidative state in patients with NSTEMI.
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Aladağ et al. (2021) conducted a cross-sectional in Non-ST elevated myocardial infarction (NSTEMI) (n=110). Non-ST elevated myocardial infarction (NSTEMI) vs. Healthy controls was evaluated on Malondialdehyde (MDA) levels (µmol/L) (p=<0.001). Non-ST elevated myocardial infarction (NSTEMI) was associated with significantly higher levels of malondialdehyde (3.14 vs 1.49 µmol/L) and ischemia modified albumin, and lower levels of superoxide dismutase and catalase compared to healthy controls.
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