Key result
Deficiency of adiponectin or T-cadherin in mice with acute renal ischemia-reperfusion injury exhibited progressive renal tubular damage, increased vascular permeability, and severe pericyte loss.
Adiponectin plays an important role in maintaining the capillary network and ameliorating renal tubular injury by binding to T-cadherin.
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Adiponectin may protect renal pericytes in ischemia; leaves open therapeutic targeting in human AKI.
Tsugawa-Shimizu et al. (2020) studied Acute renal ischemia-reperfusion injury. Deficiency of adiponectin or T-cadherin was evaluated on Renal tubular damage and vascular permeability. Deficiency of adiponectin or T-cadherin in mice with acute renal ischemia-reperfusion injury exhibited progressive renal tubular damage, increased vascular permeability, and severe pericyte loss.
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