Why the study?
Does spironolactone improve proximal tubule integrity and reduce proteinuria in hypertensive rats?
Does spironolactone improve proximal tubule integrity and reduce proteinuria in hypertensive rats?
Mineralocorticoid receptor antagonism with spironolactone improves proximal tubule integrity and reduces proteinuria via mTOR/S6K1 signaling and redox status, independent of blood pressure lowering.
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Does not support clinical use in hypertension; leaves open human translation of spironolactone's tubule effects.
Whaley‐Connell et al. (2011) studied this question.
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