May 1, 1976The Journal of Immunology

Mechanisms of Resistance Against Experimental Trypanosoma Cruzi Infection: The Importance of Antibodies and Antibody-Forming Capacity in the Biozzi High and Low Responder Mice

View Full Paper

Ask AI

Bookmark

Population

Biozzi high (Ab/H) and low (Ab/L) responder lines of mice, and non-selected Swiss albino mice

Comparison

Infection with Trypanosoma cruzi; prophylactic… vs High vs low responder lines; non-selected Swiss…

Design

Preclinical

Authors

PKPelipe Kierszenbaum JHJ. G. HowardUniversity of Iowa

Discussion

Member takes

Implication

Antibody protection in susceptible mouse strains warrants further mechanistic studies; leaves open translation to human Chagas disease.

Structured PICO

Population

Biozzi high (Ab/H) and low (Ab/L) responder lines of mice, and non-selected Swiss albino mice

Intervention

Infection with Trypanosoma cruzi (Y and Tulahuén strains); prophylactic immunization with killed T. cruzi epimastigotes; passive transfer of immune plasma

Comparator

High vs low responder lines; non-selected Swiss albino mice

Outcome

Susceptibility to Trypanosoma cruzi infection

Antibodies and antibody-forming capacity play a crucial role in resistance to experimental Trypanosoma cruzi infection in mice.

Cite This Study

Kierszenbaum et al. (1976) studied this question.

synapsesocial.com/papers/6a963f3b61dfe9432d01f2ab https://doi.org/10.4049/jimmunol.116.5.1208

View Full Paper

Ask AI

Bookmark

Mechanisms of Resistance Against Experimental Trypanosoma Cruzi Infection: The Importance of Antibodies and Antibody-Forming Capacity in the Biozzi High and Low Responder Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of Resistance Against Experimental Trypanosoma Cruzi Infection: The Importance of Antibodies and Antibody-Forming Capacity in the Biozzi High and Low Responder Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider