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This work aims to characterize Tfh and B cell responses in Chagas disease caused by Trypanosoma cruzi.

November 1, 2025The Journal of ImmunologyOpen Access

Different pathways involving Tfh cells delay parasite-specific antibody production in Trypanosoma cruzi acute experimental models 9260

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This research uncovers how Tfh cell responses affect antibody production in Chagas disease, suggesting therapeutic intervention.

This work aims to characterize Tfh and B cell responses in Chagas disease caused by Trypanosoma cruzi.
Mice were infected with Trypanosoma cruzi H1 K68 strain.
Female BALB/c and C57BL/6 mice were euthanized at 14, 28, and 49 days post-infection.
Splenic T and B cell populations were evaluated by flow cytometry.
BALB/c mice showed a strong Th2 response with massive classic Tfh cell and GC B cell expansion.
C57BL/6 mice had a Th1-skewed response with 'Th1-like Tfh' cells linked to lower parasite burden and focused antibody response.
The study highlights differences in antibody production related to Tfh cells between the two mouse strains.

Leão et al. (2025) studied this question.

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