Key result
Patients with a Fontan circulation scored significantly lower on general health than healthy peers (P = .008), while other quality of life domains and sexual well-being were comparable to normal values.
Cross-Sectional (n=21)
No
p-value: p=.008
Patients with a Fontan circulation have relatively preserved quality of life and sexual well-being but score lower on general health and face more social isolation during childhood compared to healthy peers.
Supports preserved QOL and sexual well-being in Fontan patients; leaves open targeted interventions for general health perceptions in prospective studies.
OBJECTIVE: To get an impression of the quality of life (QOL) and sexual well-being in the Fontan population, and to generate hypotheses for future research. METHODS: For this cross-sectional pilot study, questionnaires regarding health-related QOL, sexual function and fertility/pregnancy were completed by 21 patients with a Fontan circulation >16 years old, followed at the University Medical Center Groningen, the Netherlands. Semi-structured qualitative interviews were conducted in 8 patients. RESULTS: Fontan patients scored significantly lower on general health than their healthy peers (t(19)=-3.0, P = .008), whereas their scores on other QOL domains and sexual well-being were comparable to normal values. During childhood, most patients experienced physical limitations and the feeling of being an outsider, and frequently faced bullying. Regarding sexual well-being, large interindividual differences were noted. Four interviewed patients (25-30 years) reported a good sexual well-being, whereas the other interviewed patients (33-47 years) reported erectile dysfunction, low self-esteem and avoidance of sexual intercourse. Both the QOL domains mental health and role restrictions due to emotional problems were associated with female avoidance (P = .083, respectively, P = .089) and dyspareunia (P = ns respectively P = .094). In males, role restrictions due to physical problems and health change were related to sexual dissatisfaction (P = .056) respectively nonsensuality (P = .025). CONCLUSIONS: Overall, Fontan patients have a relatively preserved quality of life and sexual wellbeing but face more social isolation and bullying during childhood/adolescence than their healthy peers. Sexual problems were mainly associated with physical limitations in males and with psychosocial limitations in females. Finally, sexual dysfunction was more common in older Fontan patients, and future research has to clarify whether progressive attrition of the Fontan circulation affects the patients' QOL and sexual well-being.
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Wolff et al. (2018) conducted a cross-sectional in Fontan circulation (n=21). Fontan circulation vs. Healthy peers was evaluated on General health score (p=.008). Patients with a Fontan circulation scored significantly lower on general health than healthy peers (P = .008), while other quality of life domains and sexual well-being were comparable to normal values.
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