The level of proinflammatory cytokines: interleukins 12, 23, 17 and tumor necrosis factor in patients with metabolic syndrome accompanying severe psoriasis and psoriatic arthritis

Magdalena Pirowska; Aleksander Obtułowicz; Sylwia Lipko-Godlewska; Anna Goździalska; Katarzyna Podolec; Anna Wojas‐Pelc

doi:10.5114/ada.2018.77665

January 1, 2018Advances in Dermatology and AllergologyOpen Access

The level of proinflammatory cytokines: interleukins 12, 23, 17 and tumor necrosis factor in patients with metabolic syndrome accompanying severe psoriasis and psoriatic arthritis

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Key Points

To assess serum concentrations of proinflammatory cytokines IL-12, IL-23, IL-17, and TNF-α and evaluate their relationship with skin lesion severity, psoriatic arthritis, and metabolic syndrome risk.
Measured serum concentrations of IL-12 subunit p70, IL-17, IL-23, and TNF-α in individuals diagnosed with psoriasis and metabolic syndrome.
Compared cytokine expression profiles between patients presenting with skin-limited psoriasis and those with comorbid psoriatic arthritis.
Circulating levels of IL-17, IL-23, and TNF-α were elevated in patients diagnosed with psoriasis compared to expected baseline levels.
Patients presenting with metabolic syndrome alongside psoriasis demonstrated higher concentrations of IL-17, IL-23, and TNF-α than those without metabolic complications.
Serum levels of IL-17 and IL-23 were higher in patients with psoriatic arthritis compared to those with cutaneous psoriasis alone.

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Implication

Comparative study reveals elevated IL-17, IL-23, and TNF-α in psoriasis with metabolic syndrome, suggesting increased systemic inflammation and cardiovascular risk.

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Pirowska et al. (2018) studied this question.

synapsesocial.com/papers/6a96407bf69cd3f69201f390 https://doi.org/10.5114/ada.2018.77665

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The level of proinflammatory cytokines: interleukins 12, 23, 17 and tumor necrosis factor in patients with metabolic syndrome accompanying severe psoriasis and psoriatic arthritis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

The level of proinflammatory cytokines: interleukins 12, 23, 17 and tumor necrosis factor in patients with metabolic syndrome accompanying severe psoriasis and psoriatic arthritis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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