Key result
Psoriasis is linked to significantly elevated inflammatory markers, including CRP and Lp-PLA2.
Why the study?
The role of selected inflammatory and anti-inflammatory serum markers in the pathogenesis of metabolic syndrome and psoriasis was studied to clarify their involvement.
Are inflammatory and anti-inflammatory serum markers elevated in psoriatic patients compared to controls, and do they correlate with metabolic syndrome?
Case-Control (n=139)
Are inflammatory and anti-inflammatory serum markers elevated in psoriatic patients compared to controls, and do they correlate with metabolic syndrome?
Inflammatory markers such as Lp-PLA2 are elevated in psoriatic patients, indicating a potential link to metabolic syndrome and increased cardiovascular risk.
Answers are grounded in this paper and cite their sources.
Psoriasis linked to higher BMI and diastolic BP; leaves open whether inflammatory markers drive metabolic syndrome comorbidity.
The presented article studies the role of selected inflammatory and anti-inflammatory serum markers of psoriatic patients in the pathogenesis of metabolic syndrome (MS) and psoriasis. The study is based on the comparison between the group of psoriatic patients (74) and the control group (65). We found significantly higher BMI ( p<0.05 ) and diastolic blood pressure ( p<0.05 ) in the psoriatic patients. The values of waist circumference and BMI were significantly higher ( p<0.05 ) in the male patients compared to the men in the control group. The analysis revealed significantly higher CRP ( p<0.001 ), Lp-PLA2 ( p<0.001 ), leptin ( p<0.01 ), and resistin ( p<0.01 ) levels in the psoriatic patients. Significantly higher levels of CRP ( p<0.01 ), Lp-PLA2 ( p<0.001 ), leptin ( p<0.01 ), and resistin ( p<0.05 ) were found in the patients with MS compared to the controls with MS. The level of adiponectin was significantly lower ( p<0.01 ) in the patients with MS. Finally, we found significantly higher level of Lp-PLA2 ( p<0.001 ) in the group of patients without MS compared to the controls without MS. In conclusion, observed inflammatory and anti-inflammatory markers (CRP, adiponectin, leptin, resistin, and Lp-PLA2) are involved in both pathogenesis of MS and pathogenesis of psoriasis. The level of Lp-PLA2 indicates the presence of subclinical atherosclerosis (cardiovascular risk) in psoriatic patients.
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Vachatova et al. (2016) conducted a case-control in Psoriasis and Metabolic Syndrome (n=139). Psoriasis vs. Controls without psoriasis was evaluated on Levels of inflammatory and anti-inflammatory serum markers (CRP, Lp-PLA2, leptin, resistin) (p=<0.001). Psoriasis was associated with significantly higher levels of inflammatory markers including CRP (p<0.001) and Lp-PLA2 (p<0.001) compared to controls.
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