Key result
Plasma adiponectin levels in lean healthy women declined during pregnancy and reached their lowest level during lactation (6.88 µg/ml at 3 days postpartum vs 12.25 µg/ml at early pregnancy, p<0.001).
Observational (n=44)
No
Absolute Event Rate: 6.88% vs 12.25%
p-value: p=<0.001
Hypoadiponectinemia in lactating women is likely induced by hyperprolactinemia, which may play a role in maternal metabolic adaptations.
No clinical action warranted in healthy women; leaves open hyperprolactinemia as mediator of metabolic adaptations.
Adiponectin is an adipocyte-derived hormone involved in glucose, lipid and energy metabolism. A low plasma adiponectin concentration is associated with insulin resistance, obesity and atherosclerosis. In women, energy homeostasis is remarkably changed during gestation and lactation in order to supply sufficient nutrition for a fetus or newborn. In this study we aimed to elucidate the physiological impact of gestation and lactation on the plasma adiponectin levels and the influence of reproduction-related hormones on adiponectin secretion. We studied the longitudinal changes in plasma adiponectin concentration during pregnancy (1st, 2nd and 3rd trimester) and lactation (3 days and 1 month after the delivery) in lean healthy women (n = 22). The plasma adiponectin level declined slightly as the pregnancy advanced and reached its lowest level during lactation (12.25 +/- 0.182 microg/ml at early pregnancy vs. 6.88 +/- 0.375 microg/ml at 3 days postpartum, p < 0.001). In order to investigate the role of the lactogenic hormone prolactin in the decrease of plasma adiponectin levels during lactation, we further performed in vitro experiments using human primary cultured adipocytes. Western blotting of the adipocyte lysate and ELISA of the culture medium revealed that exogenous prolactin inhibited both production and secretion of adiponectin in a dose-dependent manner. Our results thus suggests that prolactin affects the regulation of maternal metabolism through suppression of adiponectin.
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Asai‐Sato et al. (2006) conducted an observational in Pregnancy and Lactation (n=44). Lactation vs. Early pregnancy was evaluated on Plasma adiponectin concentration (p=<0.001). Plasma adiponectin levels in lean healthy women declined during pregnancy and reached their lowest level during lactation (6.88 µg/ml at 3 days postpartum vs 12.25 µg/ml at early pregnancy, p<0.001).
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