Key result
The addition of bromocriptine to standard heart failure therapy in a 48-year-old woman with peripartum cardiomyopathy after twin delivery via oocyte donation improved her left ventricular ejection fraction from 18% to 47% at one year.
Why the study?
Peripartum cardiomyopathy is rare but life-threatening.
Does bromocriptine improve symptoms and left ventricular systolic function in a patient with severe peripartum cardiomyopathy?
Case Report (n=1)
Does bromocriptine improve symptoms and left ventricular systolic function in a patient with severe peripartum cardiomyopathy?
Bromocriptine may be an effective add-on therapy for improving symptoms and left ventricular systolic function in patients with severe peripartum cardiomyopathy who do not fully respond to standard heart failure therapy.
Answers are grounded in this paper and cite their sources.
May support bromocriptine in refractory peripartum cardiomyopathy; hypothesis-generating and requires randomized confirmation.
Peripartum cardiomyopathy (PPCM) is rare but life-threatening. We herein report the case of a 48-year-old woman with PPCM after oocyte donation and delivery of twins. Two weeks after delivery, she suffered from severe symptoms of heart failure [orthopnea, New York Heart Association (NYHA) class IV, pulmonary edema and a reduced left ventricular ejection fraction of 18%]. Although standard heart failure therapy was effective for diminishing the congestion, it was not sufficient to improve her symptoms or left ventricular systolic dysfunction. During admission, we added bromocriptine. A year later after the onset, she was in a good state with an improved left ventricular systolic function.
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Morikawa et al. (2018) conducted a case report in Peripartum cardiomyopathy (n=1). Bromocriptine was evaluated on Left ventricular ejection fraction (LVEF) and clinical symptoms. The addition of bromocriptine to standard heart failure therapy in a 48-year-old woman with peripartum cardiomyopathy after twin delivery via oocyte donation improved her left ventricular ejection fraction from 18% to 47% at one year.
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