Key result
RBP16 binds to RNA with high affinity requiring both a uridine stretch and 5' and 3' non-specific sequences, with arginine residues playing an important role in binding.
This basic science study defines the molecular interactions and sequence requirements for RNA binding by the mitochondrial Y-box protein RBP16 in Trypanosoma brucei.
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Elucidates RBP16-RNA binding in T. brucei; leaves open functional roles and therapeutic targeting.
M Pelletier (2000) studied this question. RBP16 was evaluated on RNA-binding properties. RBP16 binds to RNA with high affinity requiring both a uridine stretch and 5' and 3' non-specific sequences, with arginine residues playing an important role in binding.